Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC

Ruthenium(III) complexes formulated as K2[Ru(sar)Cl4]H2O and K[Ru(dmgly)2Cl2]3H2O containing bidentate chelates N-methylglycine (sarcosine, sar) or N,N-dimethylglycine (dmgly) as well as K[Ru(pdda)Cl2]2.5H2O complex with tetradentate 1,3-propylenediamine-N,N'-diacetato were synthesized. The complexes were obtained by direct reaction of ruthenium(III) chloride with the corresponding bidentate or tetradentate ligand followed by addition of a base (KOH). These new complexes were characterized by elemental analysis, IR and electronic absorption spectroscopy. To assess selectivity in the antitumor action of these complexes, their antiproliferative activities against human adenocarcinoma HeLa cells, human myelogenous leukemia K562 cells, human breast carcinoma MDA-MB-361 and MDA-MB-453 cells and normal immunocompetent PBM cells were determined

Synthesis and characterization of tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]-cobalt(III) seskvitoluene

A new bidentate ligand butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamate (bmFpdtc) was prepared, as the sodium salt. In the reaction of hexaaminecobalt(III) chloride with NabmFpdtc, the corresponding tris[butyl-(1-methyl-3-phenyl-propyl)-dithiocarbamato]cobalt(III), [Co(bmFpdtc)3] complex was prepared. The complex was characterized by elemental analysis, infrared, electronic absorption, 1H and 13C-NMR spectroscopy

Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(

The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)center dot nH(2)O (S,S-eddp = ethylenediamine-N,N'-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N'-di-S,S-2-propanoic acid (H-2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(2)O and uns-cis-[Pt(S,S-eddp)Br-2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin. (c) 2010 Elsevier Ltd. All rights reserved